Case Studies

The New Zealand Case Study Series

The case study series, conducted in 2021, demonstrate the safety and efficacy of Oxapex when used to manage tissue hypoxia in anaemic dogs. Oxapex has been used in veterinary clinics in New Zealand with resounding success. To date, several dogs of various breeds have received Oxapex with no serious adverse effects. The majority responded very well to Oxapex resulting in significantly improved clinical signs, and were alive and well a week after treatment with Oxapex. The causes of anaemia in these dogs were varied and included haemorrhage due to neoplasia, IMHA and gastric ulcerations.

Haemolysis

Case: NZ#1

Dog profile:

Fox Terrier
3 years old
Female

Cause of anaemia:

Immune Mediated Haemolytic Anaemia (IMHA)

Dose of Oxapex administered:

10mL/kg +10mL/kg (15 hrs apart) = 20mL/kg

Outcome:

24 hours: Survived
7 days: Alive and well

Safety:

No adverse event reported

Case: NZ#2

Dog profile:

Golden Retriever
7 years old
Male

Cause of anaemia:

Immune Mediated Haemolytic Anaemia (IMHA)

Dose of Oxapex administered:

10mL/kg

Outcome:

24 hours: Survived
7 days: Alive and well

Safety:

No adverse event reported

Summary

Dogs with IMHA can present with life threatening anaemia that needs immediate management along with immunesuppressive and other medications. In the case study series in New Zealand, 2 dogs with IMHA were successfully managed with Oxapex.

Haemorrhage

Case: NZ#3

Dog profile:

Border Collie
10 years old
Female

Cause of anaemia:

Splenic rupture

Dose of Oxapex administered:

20mL/kg

Outcome:

24 hours: Survived
7 days: Alive and well

Safety:

No adverse event reported

Case: NZ#4

Dog profile:

Labrador
10 years old
Male

Cause of anaemia:

Splenic rupture

Dose of Oxapex administered:

20mL/kg

Outcome:

24 hours: Survived
7 days: Alive and well

Safety:

No adverse event reported

Case: NZ#5

Dog profile:

Labrador
10 years old
Female

Cause of anaemia:

Systemic mastocytosis and GI bleeding

Dose of Oxapex administered:

10mL/kg +10mL/kg (12 hrs apart) = 20mL/kg

Outcome:

24 hours: Survived
7 days: Alive and well

Safety:

No adverse event reported

Case: NZ#6

Dog profile:

Sharpei
9 years old
Female

Cause of anaemia:

Splenic mass

Dose of Oxapex administered:

10mL/kg pre-operative

Outcome:

Stabilized for surgery
Euthanased during surgery due to the inoperable nature of the mass

Safety:

No adverse event reported

Summary

Anaemia due to blood loss can result in dogs becoming critically ill and requiring immediate treatment with an oxygen therapeutic. In the case study series in New Zealand, Oxapex was used successfully in 4 dogs with acute haemorrhage. There was no adverse effect noted in any of the dogs given Oxapex.

Three of the four dogs had splenic masses/rupture and haemabdomen requiring immediate surgical intervention. Oxapex was used successfully in all three dogs to stabilize their haemodynamic status and prepare them for anaesthesia and surgery. Surgery was successful in two of the three dogs. The third dog was euthanased due to the nature of the splenic mass – it was large and involved several organs in the abdomen and could not be removed safely.

One dog had systemic mastocytoma (proliferation of mast cells) with subsequent bleeding in the gastrointestinal tract from gastric ulcerations. This dog had an acute anaemic episode which was successfully managed with Oxapex.