How is Oxapex manufactured?

  • Bovine haemoglobin is harvested from blood from cattle in New Zealand.
    Trained personnel are employed to ensure a high standard of animal welfare and to avoid contamination.
  • The haemoglobin extracted from the bovine whole blood is then processed in GMP certified facilities to make Oxapex.

Why is the product not registered for use in cats?

  • Product registration for dogs is based on extensive Safety and Efficacy data acquired from laboratory and clinical studies.
  • We have commenced Safety studies in cats which we will present once complete. This will help us start the registration process for use in cats.

Why is Oxapex only registered for single use?

  • Repeated use of any product can lead to the development of anti-drug antibodies as well as other immunogenic reactions.
  • The extent of these reactions as well as the clinical relevance of these reactions is still under investigation.

Until investigations are complete, there is insufficient data to support safety of multiple doses of Oxapex. Therefore, it is only advised to use Oxapex once.


Can Oxapex be administered with other fluids?

  • Oxapex can be administered along with crystalloids, as long as a separate infusion line is used.
  • When using Oxapex alongside colloids, care must be taken, as Oxapex also exerts an oncotic pressure on its own.
  • The COP for Oxapex is around 30 mmHg, similar to that of colloids like hydroxyethyl starch (Hetastarch, Voluven, Hextend).

Can Oxapex be used in different situations of anaemia in dogs?

Oxapex can be used in any condition where tissue hypoxia exists and needs management.
Anaemia is defined as a decrease in red blood cells or haemoglobin. The end result of anaemia is decreased tissue oxygen levels. Anaemia can be mild or severe, acute or chronic, and caused by haemorrhage, haemolysis or decreased erythrocyte production.

Oxapex can be used in any situation where anaemia in dogs is present and requires management. Clinical conditions where management of anaemia is often required (and thus where Oxapex has a potential role) include:

  • Trauma resulting in haemorrhage
  • Splenic tumours
  • IMHA
  • Neoplasia
  • Intoxications and poisonings including rodenticide toxicity
  • Coagulopathies
  • Gastric ulcers

What is the half life of Oxapex?

17 – 23 hours.


What is the clearance period of Oxapex ?

By 7 days.


What is the active ingredient of Oxapex?

The active ingredient in Oxapex is hemoglobin betafumaril (bovine) 65mg/mL.